The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased frequency of missing third molars; decreased eruption frequency of developed third molars; decreased mesiodistal length of lower molars; increased percentage incidence of erupted lower incisors |
Subjects: Line C (highly sensitive to TCDD) rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered orally Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11) Age of measurement: 40 days of age |
Reference [PubMed Link] Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased length of femur in line C males; decreased bone mineral density, cross-sectional area of cortex, periosteal circumference, endosteal circumference, and polar cross-sectional moment of inertia in tibias and femurs in line C rats at 1.0 μg/kg |
Subjects: Line A (least sensitive to TCDD), B, and C (most sensitive) rats Chemical: Dioxin (TCDD) Low doses tested: 0.03, 0.1, 0.3, or 1.0 μg/kg bw; exposure timing study Route of administration: dissolved in corn oil and delivered orally Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11) Age of measurement: 40 days of age |
Reference [PubMed Link] Miettinen HM, Pulkkinen P, Jamsa T, Koistinen J, Simanainen U, Tuomisto J, Tuukkanen J, Viluksela M. 2005. Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines. Toxicol Sci 85(2):1003-1012. |